This program depicts the extraordinary efforts of the Missouri Botanical Garden to preserve and protect our natural environment on a local, regional, and international scale. It explores the many facets of the Garden's vital mission to promote biodiversity through its outstanding programs in scientific research, conservation, sustainable development, and public education. The program corrects the popular misconception of a botanical garden as merely a kind of zoo for plant life or a showcase for dazzling botanical displays. It also expands the viewer's awareness of the crucial role a botanical garden can play in the stewardship of the earth by focusing on the history and present-day activities of the nation's oldest botanical garden west of the Mississippi, which is the largest center for plant research in the world.

The storyline takes the shape of a double helix, intertwining narratives about Henry Shaw, the 19th-century visionary founder of the Garden, and Peter H. Raven, the eminent Director, whose inspirational leadership and global perspective have magnified the focus of the institution to make it a global leader for the 21st century. The episode places particular emphasis on what Peter H. Raven calls the "Unseen Garden," the many conservation, education, and research agendas that are not immediately apparent to visitors. This portion of the program showcases such things as the work of the Center for Plant Conservation, the worldwide initiatives of the Center for Conservation and Sustainable Development, and the Garden's extraordinary herbarium and rare books collection.